General Information

  • ID:  hor006073
  • Uniprot ID:  Q9W7E9
  • Protein name:  somatostatin-14
  • Gene name:  sst2
  • Organism:  Protopterus annectens (African lungfish)
  • Family:  Somatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Protopterus (genus), Protopteridae (family), Lepidosirenoidei (suborder), Ceratodontiformes (order), Ceratodontae (superorder), Dipnomorpha (subclass), Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  APCKNFFWKTFTSC
  • Length:  14(96-109)
  • Propeptide:  MQFLASLVSFLLVVWSVKATALPVEDRLSVHSNRDLTREREEMILKMISGLLDGSDNSLFGGEVTSMDIEEPLENKLEERAAYNALPQLPQRDRKAPCKNFFWKTFTSC
  • Signal peptide:  MQFLASLVSFLLVVWS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Somatostatin inhibits the release of somatotropin.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45730
  • Structure ID:  AF-Q9W7E9-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006073_AF2.pdbhor006073_ESM.pdb

Physical Information

Mass: 191202 Formula: C79H110N18O19S2
Absent amino acids: DEGHILMQRVY Common amino acids: F
pI: 8.82 Basic residues: 2
Polar residues: 6 Hydrophobic residues: 5
Hydrophobicity: -5.71 Boman Index: -1064
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 7.14
Instability Index: 3902.14 Extinction Coefficient cystines: 5625
Absorbance 280nm: 432.69

Literature

  • PubMed ID:  10398054
  • Title:  Molecular cloning of the cDNAs and distribution of the mRNAs encoding two somatostatin precursors in the African lungfish Protopterus annectens.